Love, Lust and Infatuation in Midsummer Night’s Dream Essay

Fairies, mortals, magic, love, and hate all intertwine to make A Midsummer Night’s Dream by William Shakespeare a very enchanting tale, that takes the reader on a truly dream-like adventure. The action takes place in Athens, Greece in ancient times, but has the atmosphere of a land of fantasy and illusion which could be anywhere. The mischievousness and the emotions exhibited by characters in the play, along with their attempts to double-cross destiny, not only make the tale entertaining, but also help solidify one of the play’s major themes; that true love and it’s cleverly disguised counterparts can drive beings to do seemingly irrational things. In the first part of the play Egeus has asked the Duke of Athens, Theseus, to rule in†¦show more content†¦Oberon, riddled with jealousy over his queen’s beloved â€Å"changeling†, plots to make a fool out of Titania with his magic potion so he may steal away the child. Oberons love-potion has the same effect of that of the famed Cupids arrows, it charms the sight of those it is anointed upon, and gets them to fall in â€Å"love† with the first creature they see. Oberon anoints the eyes of Titania and she ends up falling in â€Å"love† with the first creature she sees, Bottom, an actor who is rehearsing in the woods, who’s head has been turned into that of an ass by Puck. Oberon plan is successful, he is in fact able to steal away the child while his queen dotes upon Bottom, but then things start to get more complicated in the moonlit woods. Two other mortals have entered the woods that night as well, Demetrius and Helena. Helena, hopelessly in love with Demetrius, is following him on his mission to find his betrothed, Hermia, and they are also subjected to the mischievous workings of Oberon and Puck. Oberon, after observing the two young mortals, feels bad for â€Å"sweet† Helena, that even though she is professing her undying love and devotio n to Demetrius he rejects her at every turn. Demetrius hatefully tells Helena â€Å" I’ll run from thee and hide me in the brakes, and leave thee to the mercy of wild beasts’’, along with other loathsome statements, in rebuttal to Helena’sShow MoreRelated Illusion of Love in Shakespeares A Midsummer Nights Dream Essay1535 Words   |  7 PagesIllusion of Love in Shakespeares A Midsummer Nights Dream The play A Midsummer Nights Dream is centered around themes that are seemingly apparent and clear: those of true love, false love, loves blindness and the inconstancy of love. However, this pattern of the themes of love dissipate to reveal that these themes are only apparent to the reader who wants them to exist. We want Lysander and Hermia to be in love; we want Demetrius to love Helena as she loves him, but the question arisesRead More Shakespeare in my World Essay1580 Words   |  7 Pagesspring, Met we on hill, in dale, forest, or mead, By paved fountain or by rushy brook, Or in the beached margent of the sea, To dance our ringlets to the whisteling wind, But with thy brawls thou hast disturbed our sport. ~ Titania A Midsummer Nights Dream 2.1 I first truly gazed upon William Shakespeare during college. I had to do a monologue of Joan of Arc from Henry VI part I. I remember wrapping my mouth around his words, tasting him for the first time. This had not been our first introductionRead MoreWilliam Shakespeare s A Midsummers Night s Dream2289 Words   |  10 Pages Love is many things, and is also used as a reference to sight and vision such as blindness. It is much more than aesthetics and wields the power of sight, and can also cause chaos and destruction. Similarly, Shakespeare utilizes two types of blindness by love; the first being physical due to a love potion a fairy king, Oberon orders upon the humans in Shakespeare’s, A Midsummers Night’s Dream. The second, being metaphorical due to Antony’s immense amount of love towards Cleopatra, in which hindersRead MoreBrief Summary Thematic Analysis of A Midsummer Nights Dream1011 Words   |  5 PagesShakespeare’s A Midsummer Night’s Drea m are in their thoughts and actions. The true motivation behind their actions, though, is not found in witty quips by knavish fairies, but rather in the symbolic nature of the play’s setting. The varied settings in the play, from Duke Theseus’s regal estate to Fairy Queen Titania’s forest bower, serve to set the mood of every scene, and to accentuate the characters actions throughout the play. By observing the rich yet subtle backdrops of A Midsummer Night’s Dream, it isRead MoreLove in A Midsummer Nights Dream by William Shakespeare Essays666 Words   |  3 PagesLove in A Midsummer Nights Dream by William Shakespeare In midsummer night dream love is portrait in different ways . Many of the characters fall in and out of love with each other. The term lovers is used in the play to mean the four lovers Demetrius, Hermia, Helena and Lysander. They behave as individuals in the play, they also act as a group when they represent the theme of young love. There are different kinds of love in the play. One of the kinds of loveRead MoreWilliam Shakespeare s A Midsummer Night s Dream1460 Words   |  6 Pagessome true love is a simple affair, for many it is an awkward yet alluring dance around others to find that one special person that merely reduces mankind to a foolish and dumbstruck state. Such an effect is so prevalent that it may often seem as if some sort of wizardry is at play. In Shakespeare’s A Midsummer Night’s Dream, he explores this connection of magic and love, in which each of the characters-- Helena, Hermia, Lysander, and Demetrius--are charmed and enchanted in a winding love dance aroundRead More Shakespeare?s Sonnets: The Theme Of Love Essay1228 Words   |  5 Pagesremarkable age. The greatness of Shakespeare’s achievement was largely made possible by the work of his immediate predecessors, Sidney and Spenser. Shakespeare’s sonnets are intensely personal and are records of his hopes and fears, love and friendships, infatuations and disillusions that in turn acquire a universal quality through their intensity. The vogue of the sonnet in the Elizabethan age was brief but was very intense. Sir Thomas Wyatt and The Earl of Surrey brought the Petrarchan sonnetRead MoreShakespeares Sonnets: the Theme of Love1314 Words   |  6 Pagesremarkable age. The greatness of Shakespeares achievement was largely made possible by the work of his immediate predecessors, Sidney and Spenser. br brShakespeares sonnets are intensely personal and are records of his hopes and fears, love and friendships, infatuations and disillusions that in turn acquire a universal quality through their intensity. br brThe vogue of the sonnet in the Elizabethan age was brief but was very intense. Sir Thomas Wyatt and The Earl of Surrey brought the Petrarchan

Family Reflection - 1049 Words

In this course, I learned about strategies and models that help build a healthy family. My favorite thing about this class is learning how to care for others the right way and how to have successful relationships. Everyone’s family structure is different. Some people come from nuclear families and some might come from blended. It was interesting to learn that no matter what type of household a person came from, there was going to be similar challenges and issues. I did not know much about the problems that single households have until this class. In single-parent households, they have trouble managing family stress, developing new family identities, and managing maintenance tasks. Coping resources become less available and starting over†¦show more content†¦Knowing this information, it makes me want to cherish my family more and work on creating a better positive household. I liked having the opportunity to share in class our own families. Making genograms helped me u nderstand my family’s background history better and help me understand where I came from. Covert and overt rules were two terms we learned in class that describe rules that are always stated and rules that well known that do not have to be discussed. During our genogram presentations, I was able to learn other’s rules in their home. The three characteristics of an organized family is the organization of subsystems, hierarchical relationships, and clarity of boundaries. Individualization is important so that others can feel independent. A well differentiated family respect each other’s boundaries and help have a better effect on communication. There should always be a strong understanding between the parents, their marriage, and the children. There should also be an authority that keeps everything together. When everyone understands their boundaries, it avoids disengagement that makes boundaries unclear. In class, we were given our own opportunity to explain what we think family means to us. This class has helped me better understand what a successful family looks like. It was interesting to learn about family in later life too. Chapter 14 was about challenges spouses face during their later years and experience during the aging process. SomeShow MoreRelatedReflection on Family619 Words   |  3 PagesFamily Reflection †No one is ever born into Life alone. Everyone has shared the bond of family, at least at birth, and for many people it is a bond that will follow them throughout life. For many people it is the most important bond of all.† Family means many things to different people, yet the word itself can bring about a host of emotions from anyone who hears the word uttered. As a child growing up in the 60s and 70s the family dynamic was defined by the people we grew up with wereRead MoreA Reflection On The Family1299 Words   |  6 Pagesmember on a scale from 0 to 10 how he or she think their family is doing. Explain to the family that 10 is the best that they have ever been and 0 is the worst the family has ever been. Using circular questioning, a therapist will ask all members and hopefully throughout the sessions the number will increase, showing progression and improvement within the family (Gehart, 2010). Again, general strengths may include that a family has solid social support, stable employment, and an impactful spiritualRead MoreFamily Reflection Essay1480 Words   |  6 Pagesabout on holding a family together and what makes a family a whole. Hunting topic in my thoughts where is an informal topic because of what it entails. The topic was something that I like to do and take part in. In the paper I chose to write that I am against that it wasn’t cruel in anyway. That way back over hundreds of years that everyone had to hunt to survive and eat. At times many hunters got together to hunt and disperse the food evenly between each household or family. The opposing sideRead MoreA Reflection On My Family1128 Words   |  5 Pagescoming!† Today is the day my family and I are leaving Tucson, Arizona. We are moving to a small town located in Virginia. I’m very nervous but also excited. We are leaving Arizona because my stepdad just retired from the military and he wants to live somewhere where we are surrounded by vast land. Also, on the plus side my grandparents will be very close to us. I’m going to miss all of my friends, especially my best friend Kayla. Maybe this move is the best thing for my family. I never realized howRead MoreReflection Of My Family Dinner887 Words   |  4 PagesReflection When I was six years old, my mother moved my sister Sara and me into her boyfriend’s house. From the outside, the house looked like all the others that surrounded it in the neighborhood. It was a mid-sized white house that needed a new paint job. On the inside, however, it reeked of alcohol. Everything in the house was covered in dust like it hadn’t been cleaned since it was built. At 6:11pm every night my mother’s boyfriend Jon would burst through the door after work, and shove my motherRead MoreGeneral Reflection : My Family2027 Words   |  9 Pages General Reflection/Overview My family is deemed to be what is referenced as a nuclear family. A father, mother, and their offspring biological and adopted living together under one household. My family was of low socioeconomic status and due to this position, we were raised in a low-income neighborhood. However, that did not affect how my mother and father reared their family. I am the third child in a family of five. My role in the family was that of a helper to my mother of household dutiesRead MoreGeneral Reflection : My Family2023 Words   |  9 PagesGeneral Reflection/Overview My family is deemed to be what is referenced as a nuclear family. A father, mother, and their offspring biological and adopted living together under one household. My family was of low socioeconomic status and due to this position, we were raised in a low-income neighborhood. However, that did not affect how my mother and father reared their family. I am the thirdRead MoreDefining Family and a Personal Reflection572 Words   |  3 Pagesexplaining how I define family. I will also include my immediate and extended family. I will also describe what family means to me, how mine differs from other families in my neighborhood, and also how they are similar. I will also describe my family’s ethnicity and how it may affect any of my family’s health. To me, family is a group of people that are brought together by blood, adoption, or marriage. I also believe that people do not have to be blood-related to be considered a family. If two or moreRead MorePersonal Reflection On Family Nursing936 Words   |  4 Pages Family nursing promotes, maintains, and restores health of families considering the history and future of its members (Kaakinen, Coehlo, Steele, Tabacco, Hanson, 2015). The purpose of the paper is to discuss my nursing experiences related to the four approaches to family nursing, including family as context, as a client, as a system, and as a component of society (Kaakinen et al., 2015). Over the course of a week in the intensive care unit, all four approaches to family nursing were implementedRead MoreReflection About My Family Background1239 Words   |  5 Pagesmy mother’s side of my family originated from somewhere in Ireland. Although, I do not know specifics, I know that the Irish heritage was still very valued throughout my great grandparents as well as grandparents. Unfortunately, my great grandmother passed away when my own mother was very young and so the Irish culture was not talked about or even understood as much. Even though I do not know specifics of my family heritage it’s amazing knowing that at one point my family line started across the

Use Of Bone Marrow Transplants Health And Social Care Essay Free Essays

The bone marrow is a sponge-like tissue found in the centre of certain castanetss that contains root cells that are the precursors of ruddy blood cells ( red blood cells ) that carry O to the tissues in the organic structure, white blood cells ( leucocytes ) that aid battle infections and to assistance in the immune system and thrombocytes which help with blood curdling. Each of these cells plays a important function in the organic structure by keeping normal physiological map. The bone marrow is a critical portion of the human organic structure. We will write a custom essay sample on Use Of Bone Marrow Transplants Health And Social Care Essay or any similar topic only for you Order Now A bone marrow graft is when particular cells ( called root cells ) that are usually found in the bone marrow are taken out, filtered, and given back either to the same individual or to another individual. It involves pull outing bone marrow incorporating normal root cells or peripheral root cells from a healthy giver, and reassigning it to a receiver whose organic structure can non fabricate proper measures of normal blood cells. Infusion of haematopoietic root cells from oneself or another individual normally follows high dose chemotherapy and/or irradiation. The end of the graft is to reconstruct the receiver ‘s blood cells and immune system and hopefully bring around the implicit in disease In patients with leukaemia, aplastic anaemia, and some immune lack diseases, the root cells in the bone marrow have malfunction, bring forthing an inordinate figure of faulty or immature blood cells as in the instance of leukaemia or low blood cell counts in the instance of aplastic anaemia. The immature or faulty blood cells interfere with the production of normal blood cells, accumulate in the blood stream and may occupy other tissues so bone marrow graft enables the doctors to handle these diseases with aggressive chemotherapy and/or radiation by leting replacing of the morbid or damaged bone marrow after the chemotherapy/radiation intervention. While bone marrow grafts do non supply 100 per centum confidence that the disease will non repeat, a graft can increase the likeliness of a remedy or at least prolong the period of disease-free endurance for many patients. Bone marrow organ transplant is an effectual intervention for a assortment of haematological tumors, furnace lining lymphoma, and some solid tumours. An increasing figure of bone marrow grafts are performed every twelvemonth. The therapy has been used to rectify a assortment of marrow failure provinces, congenital mistakes of metamorphosis, immune lacks, haematological malignances, and even solid tumours. The first successful grafts were performed with root cells derived from the marrow of indistinguishable twins ( syngeneic organ transplant ) ; nevertheless, application of organ transplant therapy broadened with the usage of root cells obtained from either related or unrelated givers ( allogeneic organ transplant ) appropriately matched at the human leucocyte antigens ( HLA ) , or even with a patient ‘s ain root cells ( autologous organ transplant. Deciding on type of BMT depends on type and phase of disease, handiness of root cells, age, public presentation position and the c linical status of patient Bone marrow organ transplant is required in the sense that is to remedies many diseases and malignant neoplastic diseases. When a kid ‘s bone marrow has been damaged or destroyed due to a disease or intense interventions of radiation or chemotherapy for malignant neoplastic disease, a marrow graft may be needed to rectify the abnormalcy. It is besides required to replace morbid, non-functioning bone marrow with healthy working bone marrow ( for conditions such as leukaemia, aplastic anaemia, and reaping hook cell anaemia ) . It is besides indispensable to replace the bone marrow and reconstruct its normal map after high doses of chemotherapy or radiation are given to handle a malignance in a procedure called â€Å" deliverance † which is usually used for diseases such as lymphoma, neuroblastoma, and chest malignant neoplastic disease. The procedure is besides of import in the replacing of bone marrow with genetically healthy working bone marrow to forestall farther harm from a familial disease procedure. Literature reappraisal Bone marrow organ transplant ( BMT ) or haematopoietic root cell organ transplant ( HSCT ) is a medical process in the field of haematology and oncology that involves organ transplant of haematopoietic root cells ( HSC ) .It is most frequently performed for people with diseases of the blood or bone marrow, or certain types of malignant neoplastic disease. Transplant of either allogenic or autologous bone marrow has become an progressively applied and successful therapy for patients with haematological malignances and certain solid tumours. BMT is an illustration of a extremely proficient therapy that offers hope to patients with bone marrow failure or assorted malignances. Bone marrow organ transplant is much more dearly-won â€Å" up-front † but possibly non more dearly-won long-run than alternate therapies. Over the past 40 old ages, bone marrow organ transplant and haematopoietic root cell organ transplant have been used with increasing frequence to handle legion malignant and nonmalignant diseases. Post-World War II â€Å" Cold War † frights of atomic warfare stimulated involvement in the effects of radiation on the human organic structure. Early surveies with animate beings has shown that bone marrow was the organ most sensitive to the detrimental effects of radiation and for that ground the reinfusion of marrow cells was used to deliver lethally irradiated animate beings. In one survey done in 1950s, patients were given deadly doses of radiation to handle leukaemia and many had haematological recovery following this intervention, but finally all patients succumbed to get worse of their malignances or to infections. In the 1950s and 1960s, about 200 allogeneic marrow grafts were performed in worlds, with no long-run successes. However, during this clip, organ transplant utiliz ing indistinguishable twin givers has brought a just sum of success and provided a important foundation to go on clinical research in the field. Hematopoietic root cell organ transplant remains a hazardous process with many possible complications ; it has traditionally been reserved for patients with dangerous diseases. While on occasion used by experimentation in nonmalignant and nonhematologic indicants such as terrible disenabling auto-immune disease and cardiovascular, the hazard of fatal complications appears excessively high to derive wider credence. Although economic analyses appear comparatively simple, reading and usage can be debatable. Several economic analyses have identified complications that occur often and impact the reported cost-effectiveness of high-dose chemotherapy. Attempts to cut down the cost of bone marrow organ transplant have focused on new schemes to more efficaciously command these complications. The debut of new engineerings to rush engraftment, to better patient choice methods, and the shifting of attention to outpatient scenes all have resulted in important decreases in continuance of infirmary stay, treatment-related mortality, and costs. More surveies of long-run results are needed for graft and non graft intervention options to steer present and future applications of this intervention option. Expanded indicants for graft continue to be explored. Preliminary information suggest a possible function for graft in the intervention of autoimmune diseases such as lupus, multiple induration, systemic induration, and juvenile rheumatoid arthritis. In add-on, in utero graft holds promise for early rectification of familial disease, with some success already demonstrated with the immunodeficiency syndromes. The accent of current research is chiefly directed at diminishing toxicity and GVHD while increasing the pool of possible givers by developing techniques to traverse the traditional HLA histocompatability barriers more successfully. Grafts are performed with increasing grades of mismatch. With the promotions in techniques, indicants, and supportive therapy, the graft of haematopoietic root cells continues to be an forward field in the intervention of human disease. Once a disease procedure has been identified and graft is considered as a possible therapy, an appropriate giver must be identified. The best possible lucifer consequences in the least complications. For allogeneic grafts, HLA histocompatability typewriting is performed for immediate household members ab initio utilizing serologic typewriting. Fully matched household members provide the most compatible lucifers because they frequently portion minor HLA antigens non normally included in proving. Before undergoing BMT, patients should undergo a series of trials and processs for testing and readying based on the patient ‘s disease procedure and medical history. There is besides pre-transplant instruction where graft squad and the patient meet to discourse the consequences of the testing, intervention options and the intervention program. Transplant conditioning is the done with the chief purpose of destructing unnatural cells or malignant neoplastic disease cells throughout the pa tient ‘s organic structure utilizing conditioning regimen which consist of chemotherapy, radiation therapy or both. The crop processs for autologous or allogeneic BMT are similar and are depended on the undermentioned factors: The patient ‘s physical status, donor handiness and insurance blessing. The BMT process involves three stages. In the first stage, enduring 5 to 14 yearss, the bone marrow receiver is prepared for the transplant and immunosuppressive and cytotoxic chemotherapy are administered and irradiation is used to enable the receiver to accept the transplant, to forestall transplant rejection, and in instances of acute leukaemia to extinguish residuary leukaemia. In the 2nd stage, bone marrow is from the giver is intravenously administered to the transplant receiver. Donors and receivers of bone marrow grafts must hold HLA compatability. The 3rd stage involves a period of waiting for the bone marrow to ingraft and work usually in the receiver. During the clip required for engraftment, the transplant receiver is vulnerable to infection, hemorrhage, terrible weight loss, rejection of the transplant, and graft-versus-host disease ( GvHD ) . Some of the posttransplant intervention typically includes cyclosporin A and perchance other chemotherapies to either prevent or dainty transplant versus-host disease ( GVHD ) . The results of the therapy depend on many factors such as: Improvements in supportive attention, antibiotic regimens, and DNA-HLA is associated with favourable result. The patient ‘s province of wellness or stable disease or disease in remittal is associated with better results than those transplanted during a ulterior disease stage or with relapsed disease. Young age at clip of graft and besides CMV-negative position of receiver and giver enhance the likeliness of endurance. The sum of haematopoietic cell dose given at clip of graft may besides rush engraftment and better result though it has an increased hazard of GVHD. Bone marrow organ transplant is one of legion new medical engineerings that have raised complex legal and ethical issues. Laws refering to medical progresss have been passed in response to the demand to decide struggles in judicial sentiments instead than expectancy of those issues which impinge on single autonomies. Some of the legal and ethical issues are malpractice claims, proving prospective givers for AIDS, sale of bone marrow, informed consent for both giver and receiver, and inquiries that arise when the giver is a kid. Pre-counseling is done to the patient prior to any intercession since information helps the patients in the undermentioned ways: To build positive attitudes in relation to the disease, enables a better response to the state of affairs, facilitates patient ‘s effectual engagement in the determination devising procedure and future programs and besides plays a important or cardinal function in wellness. Furthermore, the patients have a legal right to be inf ormed about their disease. Decision: The bone marrow is a critical portion of the human organic structure. Bone marrow organ transplant is an effectual intervention for a assortment of haematological tumors, furnace lining lymphoma, and some solid tumours. The most of import cell needed for successful organ transplant is the haematopoietic root cell whose major beginnings are bone marrow, peripheral blood, and cord blood. These can be obtained from assorted givers as either autologous or allogeneic. Deciding on type of BMT depends on type and phase of disease, handiness of root cells, age, public presentation position and the clinical status of patient. The procedure is besides of import in the replacing of bone marrow with genetically healthy working bone marrow to forestall farther harm from a familial disease process.. BMT is an illustration of a extremely proficient therapy that offers hope to patients with bone marrow failure or assorted malignances. Bone marrow organ transplant is much more dearly-won â€Å" up-f ront † but possibly non more dearly-won long-run than alternate therapies. Hematopoietic root cell organ transplant remains a hazardous process with many possible complications ; it has traditionally been reserved for patients with dangerous diseases. The accent of current research is chiefly directed at diminishing toxicity and GVHD while increasing the pool of possible givers by developing techniques to traverse the traditional HLA histocompatability barriers more successfully. With the promotions in techniques, indicants, and supportive therapy, the graft of haematopoietic root cells continues to be an forward field in the intervention of human disease. With the promotions in techniques, indicants, and supportive therapy, the graft of haematopoietic root cells continues to be an forward field in the intervention of human disease. Mentions Frick, E. , Motzke, C. , Fischer, N. , Busch, R. , A ; Bumeder, I. ( 2005 ) . Is perceived societal support a forecaster of endurance for patients undergoing autologous peripheral blood root cell organ transplant? Psycho-Oncology, 14, 759-770. Holland, J. A ; Alici, Y. ( 2010 ) . Management of hurt in malignant neoplastic disease patients. Journal of Supportive Oncology, 8 ( 1 ) , 4-12. Jacobsen, P. ( 2009 ) . Promoting evidence-based psychosocial attention for malignant neoplastic disease patients. Psychooncology, 18, 6-13. Jacobsen, P. A ; Jim, H. ( 2008 ) . Psychosocial intercessions for anxiousness and depression in grownup malignant neoplastic disease patients: accomplishments and challenges. A Cancer Journal for Clinicians, 58, 214-230.A NCCN Clinical Practice Guidelines in Oncologya„? Distress Management ( Version 1.2010 ) . A © 2009 National Comprehensive Cancer Network, Inc. Available at: NCCN.org. Accessed [ Febuary 3, 2010 ] . Ranson, S. , Jacobsen, P. , A ; Booth-Jones, M. ( 2006 ) . Validation of the hurt thermometer with bone marrow graft patients. Psycho-Oncology, 15, 604-612. Wells, K. , Booth-Jones, M. , A ; Jacobsen, P. ( 2009 ) . Do get bying and societal support predict depression and anxiousness in patients undergoing hematopoitic root cell organ transplant? Jouranl of Psychosocial Oncology, 27, 297- 315. Williams, S. A ; Dale, J. ( 2006 ) . The effectivity of intervention for depression/depressive symptoms in grownups with malignant neoplastic disease: a systematic reappraisal. British Journal of Cancer, 94, 372-390.A The usage of allogeneic haematopoietic cell organ transplant ( HCT ) has increased as new techniques have been developed for organ transplant in patients who antecedently would non hold been considered HCT campaigners. However, its efficaciousness continued to be limited by the development of frequent and terrible ague GVHD. The complex and intricate pathophysiology of acute GVHD is a effect of interactions between the giver and host innate and adaptative immune responses. Multiple inflammatory molecules and cell types are implicated in the development of GVHD that can be categorized as: ( 1 ) triggers that initiate GVHD by therapy-induced tissue harm and the antigen disparities between host and transplant tissue ; ( 2 ) detectors that detect the triggers, that is, procedure and present alloantigens ; ( 3 ) go-betweens such as T-cell subsets ( naif, memory, regulative, Th17 and natural slayer T cells ) and ( 4 ) the effecters and amplifiers that cause harm of the mark variety meats. These multiple inflammatory molecules and cell types that are implicated in the development of GVHD have been described with theoretical accounts that use bit-by-bit Cascadess. Herein, we provide a fresh position on the immunobiology of acute GVHD and briefly discuss some of the outstanding inquiries and restrictions of the theoretical account systems. Bone Marrow Transplantation ( 2010 ) 45, 1-11 ; doi:10.1038/bmt.2009.328 ; published online 30November 2009 Fifty old ages ago, Billingham1 identified three requirements for the development of GVHD: ( 1 ) the presence ofimmunocompetent cells in the giver inoculant, ( 2 ) the inability of the receiver to reject the giver cells and ( 3 ) a histocompatibility difference between the giver and receiver. Billingham RE. The biological science of graft-versus-host reactions. Harvey Lect 1966-67 ; 62: 21-78. Some future research waies 1. Impact of type of harm ( programmed cell death V mortification of different cellular subsets ) , specific DAMPs, unfertile redness and complement system. 2. Contribution of host intestine microbiome and the giver immune position. 3. Determine GVHD antigenic repertory, place immunodominant antigens. 4. Understand the function of both professional ( DCs, macrophages ) and semi-professional ( B cells ) giver and host APC subsets, the relevancy and mechanisms of cross-presentation. 5. The mechanisms and function of donor Th distinction, regulative, memory T cell, and NK cell subsets. 6. Functions of specific effecter tracts in doing distinguishable mark organ harm. 7. Determinants of mark organ specificity, the function of mechanisms of fix and neovascularization in the badness of harm. 8. Mechanisms and effect of immunosuppression induced straight by GVHD. 9. Development of an incorporate systems attack for understanding the biological science of GVHD. Biology of ague GVHD S Paczesny et Al 7 Bone Patient Education / Curative patient instruction ( TPE ) a continous procedure integrated in wellness attention aˆ? patient centred aˆ? adapted to the development of unwellness and patientA?s life-stile aˆ? portion of the long-run direction of unwellness aˆ? structured and organized aˆ? benefited by appropriate pedagogic means* aˆ? multiprofessional, interdisciplinary and intersectonial. *I. Rabbone, 2007 The function of the patient is cardinal in taking attention of himself in order to lend to his conditions and be responsible of his status, and to be a squad resource â€Å" without costs † ( Rabbone I. , 2009 ) . **J. Philips, 1998 Patients have a legal right to be informed about their disease butaˆÂ ¦they assume it is non ever respected ( Visser et al. , 2009 ) . Information is a demand of patients as it allows them: – to build positive attitudes in relation to the disease, – a better response to the state of affairs and – an effectual engagement in the decission doing procedure and hereafter programs aˆ? Information besides has a cardinal function in wellness instruction plans Patient need information about: – Disease – Treatment options – Treatments results – Symptoms – Side effects – Quality of life aˆ? Information should be delivered in an synergistic manner aˆ? Information/education is necessary in all stages of the graft S Setting. Pick a private location. P Perception. Find out how the patient positions the medical state of affairs. I Invitation. Ask whether the patient wants to cognize. K Knowledge. Warn before dropping intelligence. E Empathy. Respond to the patient ‘s emotions. S Strategy/Summary. Once they know, include patients in intervention determinations * W. Baile et Al. â€Å" Out of 5 patients, merely 1 to 2 follow the instructions given by physycians. The others follow a â€Å" ain version † of the therapy and hold their thoughts sing their disease. They will ne’er squeal them. They are incorrect, but who is guilty? † J. P. Assal ( 1999 ) Literature McPherson CJ, et Al. Effective methods of giving information in malignant neoplastic disease: a systematic literature reappraisal of randomized controlled tests. J Public wellness Medecine 2001 ; 23 ( 3 ) : 227-234 aˆ? Thomas R, et Al. Anxiety and depression: consequence on patients ‘ penchants for information following a diagnosing of malignant neoplastic disease. Annalss of Oncology 1998 ; 9: 141 aˆ? Lobb EA, et Al. When the safety cyberspace of intervention has been removed: Patients ‘ unmet demands at the completion of intervention for hematologic malignances. Patient Educ Couns ( 2009 ) ; Department of the Interior: 10.1016/j.pec. 2009.02.005 aˆ? Mank A, et Al. An synergistic Compact disc read-only memory to inform patients about Stem Cell Transplant. Patient Educ Couns 2008 ; 73: 121-126 aˆ? Downs S. Ethical issues in bone marrow organ transplant. Semin Oncol Nurs 1994 ; 10: 58-63 aˆ? Lee SJ, et Al. Discrepancies between patient and physician estimations for the success of root cell organ transplant. J Am Med Assoc 2001 ; 285: 1034-8 aˆ? Andrykowski MA, et Al. â€Å" Returning to normal † following bone marrow organ transplant: results, outlooks, and informed consent. Bone Marrow Transplant 1995 ; 15: 573-81 A elaborate appraisal of BMT receiver ‘s emotional, societal, and psychological wellbeing before BMT is necessary to supply optimum, holistic attention. Distress and depression should be recognized, monitored, documented and treated quickly during the BMT intervention. BMT patients need to be screened at their pre-transplant assignment, at appropriate intervals, and as clinically indicated during the BMT procedure. Distress and depression should be recognized, monitored, documented and treated quickly during the BMT procedure to guarantee positive patient results. How to cite Use Of Bone Marrow Transplants Health And Social Care Essay, Essay examples

The Economic Contribution of Melbourne- Free-Samples for Students

Question: Prepare an Essay on the Economic Contribution of Melbourne's Foodbowl. Answer: Introduction According to Victoria in Future (2015), Melbourne is second biggest Australian city with a population of around 4.6 million people. The area surrounding Melbourne city are conducive for agriculture, mostly producing vegetables. With growing population in Melbourne so as need for more increase. Increase in industrialization has occupy land which initially was used for food production. This has result to food production decline, with urbanization posing threat to food production. There is need to have good information on where to use land for construction, farming, urban use and recreational purpose. Deloitte Access Economics has access the use of land to farm at Melbourne University. Agricultural land Melbourne food bowl consist of three parts that is inner Melbourne or urban area this is the most populated local government area. Where most people in Melbourne conduct commercial activities. The other part is the peri-urban area or the interface Melbourne, this is the residential area which makes the greater Melbourne. Outside interface is the rural area and coastal region, which makes the outer food bowl. The residents of these areas mainly engage in farming. The food bowl accounts for more than 1.7 million hectares, around 12% of Victorias 14.8 million hectares of agricultural land. Most of Melbourne food bowl is located in outer Melbourne outside the city in rural areas which consist of 9% of Victorias agricultural land. The inner Melbourne make up 0.1% and the interface Melbourne 3%, it is evident as one move away from city center more land for agriculture is available. According to The economic contribution of Melbournes food bowl (2015, p4). Agricultural production The agricultural production within three regions of Melbourne increase with increase in availability of agricultural land. The urban region has less land for agricultural activities producing the least agricultural products in the food bowl. As one moves away from the urban areas more land is available for agricultural purpose. The outer region produces more as compared to the interface region as it has more land available to conduct agriculture. The outer region or the rural area is most productive part in Melbourne food bowl.(Deloitte, 2015, p. 9) Melbourne population growth As per June 2016 Melbourne population was 4.6 million people making it the second most populated city in Australia. The population is expected to grow and the food demand In Melbourne is likely to rise as follow. From 4.6 million in 2016, 5 million in 2021, 5.5 million in 2026, 6 million in 2031, 6.4 million in 2036, 6.9 million in 2041, 7.3 million in 2046 to 7.8 million in 2051. The food demand in Melbourne city is expected to grow by 70% by 2051. This will require more land for agricultural land as compare to now. Thus there is need to know where to preserve for agricultural purposes and to cater the growing food demand in Melbourne. Methodology The data sources were secondary from ABS Census of population and housing, mesh block counts (2010-11), which show the percentage of population in each region as per Deloitte Access economics. Descriptive statistics were used to summarize data and visualize it. Graphical data presentation were used such as pie chart and bar graph. Pie chart was used to visualize Victoria Land for agricultural purpose by percentage, bar graph was used to represent value of production in Melbourne food bowl and population of Greater Melbourne from 2011to 2051. The data was in categorical form, which are summarized using pie chart or bar graph. The report failed to use the measure of location and measure of dispersion which are used on numerical data for summarization and histogram is used for visualization.(Australian Bureau of Statistics (ABS), 2012) Conclusion The largest agricultural land is in rural area of Melbourne city which also contribute largest part of Melbourne food bowl. These areas are located in outskirt of the city where there is few people and large portion of the land suitable for agriculture. With population estimated to grow by 70% by 2051 the urban area of Melbourne with slowly occupy the interface region, occupying land which initially was used for agriculture. The food demand will increase as agricultural production decrease due to urbanization. The available information should be used to allocate land for agriculture to cater food demand for the growing population in Melbourne.(Carey, 2015) References Timmons, D., Wang, Q. and Lass, D. (2008), Local Foods: Estimating Capacity, Journal of Extension, vol 46 (5), available at https://www.joe.org/joe/2008october/a7.php. Australian Bureau of Statistics (ABS) (2012), Value of agricultural commodities produced, 201011, available at https://www.abs.gov.au/ausstats/abs@.nsf/mf/7503.0. Carey, R., Larsen, K. and Sheridan, J. (2015), The role of cities in climate resilient food systems: A Foodprint Melbourne briefing, Victorian Eco-Innovation Lab, The University of Melbourne

If youth knew, if age could Essay Example

If youth knew, if age could Essay In act, children too seem to be very mature and learn to fend for themselves in pressure driven times. They tend to be more capable of handling different situations, though being underestimated by their parents and teachers. To my way of thinking, wisdom does not necessarily point to a higher capacity to figure out something or Judge acts with prudence it means caring about your life, learning from your mistakes without repeating them from vanity and being smart enough to put in balance all the consequences that a choice might have. Disobedient. Undisciplined. Rebellious. Negligent. Disrespectful. These are few of the words a teenager is called every day. Do they help him Do they try to make any good No, they do nothing but discourage, even weaken the youngster, making him not trust himself Think of a young little boy who has lived all his life on his own, he anymore. Passed through complicated life roads alone, without any support, from anybody, facing many problems sometimes succeeding, sometimes failing, learning from every minute of his life, but still, he managed to overcome every hardship. He has learned owe to shelter when it rains, how to warm up when its cold and what is more, how to take care of himself when his family should have. As far as I believe, every youth may hold all of the knowledge in the world, and may have the answers to all questions, without knowing this. Of course, I am slightly exaggerating but I am sure you understand my point, which is that young people seem to know more than the elderly in different situations, even though they lack experience. They will try to fix your computer and ninety-nine times of one hundred they will certainly succeed. We will write a custom essay sample on If youth knew, if age could specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on If youth knew, if age could specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on If youth knew, if age could specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Why is so Firstly because they prove to be more patient than an adult. They have the capacity to remain calm for longer, as a consequence of their tender age. Secondly, they are fast learners, capable of learning new skills in no time, due to their desire and curiosity to understand the unknown. Moreover, the 20th century defined the youth as those that had to educate themselves on emerging streams of knowledge and were exonerated from demanding Jobs and responsibilities. The media forces have also lead the children of today to be more informed, and more ailing to take over what life has to offer to them. Therefore I feel that the road of life does not always take us where we expect. For many of us there is a great desire and longing to do something with our lives. We have our dreams and wishes. We have waited a long time for independence, so it is our turn to make decisions, to call the shots and forge our own way through the world.

50 Open Source Resources for Writers

50 Open Source Resources for Writers 50 Open Source Resources for Writers 50 Open Source Resources for Writers By Daniel Scocco Why pay for Word processors, image editing software and other tools when there are solid open source alternatives around? The guys from Job Profiles just compiled in fact a big list with 50 open source resources for writers. Below you will find my favorite ones: Open Office (office suite; forget Microsoft) NotePad++ (best notepad around, especially for editing HTML and other codes) AbiWord (very light word processor) JaLingo (desktop dictionary) Ever Note (organize your chapters and essays) Sonar (track your publishing contacts) PDF Creator (word as good as the Adobe software) Prompt (change your prompt to get inspired) GIMP (alternative to Photoshop) WordPress (if you need a website, go with WordPress) Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Writing Basics category, check our popular posts, or choose a related post below:5 Uses of Infinitives45 Synonyms for â€Å"Old† and â€Å"Old-Fashioned†Testimony vs. Testimonial

Market mechanism and public service delivery Essay

Market mechanism and public service delivery - Essay Example In the last few decades,public administration has witnessed a deep process of reform in order to "make publicly-owned services and enterprises more business - like".For, public administration has increasingly translated into public governance and huge behemoths in the public sector are expected to be run more efficiently at reduced costs. In other words, it is expected that the public administration become competitive in delivering goods and services. Governments are expected to strategise a country's developmental priorities by providing an efficient, responsive and transparent public administration. Countries have now moved to a mix of market-based or competitive governance and civic-based or partnership governance. This has been brought about by the changing role of the state and the growing businesslike and managerial approach to the operations of Public Administration. A new fragmented and complex world of markets and networks has pushed governments to move from a direct deliver y of services to a more general coordination and control of government functions. While, there is substantial scope for increase in delivery of public services through the market mechanism, there are several limitations and impediments too.In a globalised era, public administration, or the delivery of public services considered as universal needs and much needed socio-economic infrastructure to civil society are proving to be a tough and complex task. Since Public Administration includes within its ambit political, economic and social governance, governments across the world are having to function in an environment marked by increased public scrutiny. This has arisen out of increasing democratization and the diffusion of ideas arising from the implosion of information and communication technologies. Text of the article Since the time of Plato, Aristotle and Kautilya, good public managers have been recognized as those with sound judgement, a sense of justice and courage to take action on behalf of the good of society. Traditionally, public administration entities ie government institutions responsible for providing vital services have been state-centric, huge, self sufficient monoliths, hierarchical in their relations and also inclined towards a controlling order. Since early Public service mechanism 2 times, the public administration in countries has been providing services essential to society, some of them considered as fundamental rights of the citizens, like the right to water. In addition, law and order, health, education and building infrastructure viz. roads, transportation including railways and aviation, telecommunication, sewage, energy and a host of other services have come within the ambit of public administration. Publicly owned services and industries are controlled by the central governments. These state-owned enterprises or services do not generate any profit and provide essential services for the entire population. The cost of providing these services is met from taxation money. Local bodies are entrusted with certain civic functions including waste management, maintenance of parks etc. The main advantage in public owned enterprises or services is that jobs for workers in these institutions are secure and unemployment does not

The Puerto Rican Americans Assignment Example | Topics and Well Written Essays - 750 words

The Puerto Rican Americans - Assignment Example The cruel Spanish colonial leaders took them as captives and massacred them. Puerto Rico came under the territory of United States in 1898 just after the Spanish-American war ended. In the Treaty of Paris, Puerto Rico was surrendered by the Spain to the United States. The U.S government started introducing measures to solve the crucial issues of the island, Puerto Rico. Essential actions were taken to bring the economic and social conditions of the island under control. Just after the event of Puerto Rico, coming under the United States colony, migration began. At the early stage, migration was less due to the poor financial conditions of the residents of Puerto Rico. As the economic and social conditions of Puerto Rico enhanced; and the United States-Puerto Rico relations became stronger, immigrations increased. By the year 1920, not more than 5000 Puerto Ricans lived in New York City. When the World War I began, it was seen that more and more Puerto Ricans were shifting to U.S and nearly 1000 Puerto Ricans got employed in the U.S army. The number of Puerto Ricans soldiers in the U.S army increased to 100,000 during the World War II. The World War II period exhibited a phase of the first great migration of Puerto Ricans to United States. All these events displayed a very strong bond which had formed between the United States and Puerto Rico. The economic and social factors were responsible for the huge migration from the island to the mainland. Firstly of all, the island was suffering from overpopulation; and secondly, the mainland had plenty of work opportunities which were attracting many poverty stricken citizens of Puerto Rico. Since then New York City became the central point of migrations. Later on in early 1960s the rate of migration decelerated. Back and forth flow of the people continued but at a comparatively slow pace. But in late 1970s due to recession again the migration of people from the island to the mainland increased tremendously and many of the people decided to settle in New York City permanently. According to the statistics of U.S Census Bureau, by the year 1990 no less than 2.7 million Ricans were living in the New York City. (Green) Challenges and Accomplishments: Due to autocratic control of the Spanish over the Puerto Rico Island, its citizens had to undergo enormous much pain and brutality. Secondly, no one was taking care of the economic and social conditions of the society due to which the residents of the country had to grieve a lot. Apart from this, over population was another problem which gave rise to the problem of unemployment and very poor living standards. The cost of migration was not affordable by many. Moreover, migrated Ricans got the job of soldiers in the army as it was war time and there was no guarantee of their lives and family at risk due to the ongoing events of war. After passing these hurdles, Puerto Rican Americans achieved a lot, including the opportunity to work, protection from the Uni ted States, freedom from the cruel rule of the Spanish, a good place to settle down and that was New York. Plus, they could begin their lives again and live peacefully; the major problems of the island were looked upon and taken care of under the governance of United States; and the island regained its economic and soci

MIH548 - Theory Based Research - Mod 1 Case Assignment Essay

MIH548 - Theory Based Research - Mod 1 Case Assignment - Essay Example This is principally arrived at through deductive and inductive logic and parsimony within the limits and domains of science and related rational presuppositions. It is to be remembered that experiments and observations generate data, and in some point there would be a need for interaction between data and theory, which leads the methodology beyond the realm of deductive rationality to collection of data and their interpretation in such a manner that the whole affair can be replicated (Wilson 1952). John Snow is famous as an epidemiologist who first demonstrated conclusively that cholera is actually caused by microorganisms, and he deductively established that these organisms affect the human beings through transmission by food or water. His epidemiologic work is now considered as the classic reference of modern epidemiology and has been termed by Frost to be a â€Å"nearly perfect model† (Morabia 2001). Snow’s work on cholera epidemic in London would not have been possible without the scientific disease surveillance methodologies enacted by Farr, which indicated the importance of water supply in South London. Based on the data collected by Farr, Snow could reach a conclusion about the causation of cholera epidemics in London. Based on the distribution of mortality data from cholera, it was possible for him to locate the households that were getting comparatively cleaner water and hence lesser incidence of the disease and related death rates (Morabia 2001). The necessity of a controlled experiment in order to implicate the water supply in the London cholera epidemic in 1848-1849 was understood by both, but Snow got an intellectual leap from the data collected by Farr, through the simple method of grouping the households based on a definition of exposure to the causative agent. Despite the thought of controlled experiment

Symptoms Of Disorganized Schizophrenia Psychology Essay

Symptoms Of Disorganized Schizophrenia Psychology Essay Schizophrenia  is a severe mental disorder characterized by delusions, hallucinations and physical agitation; which typically causes such patients to severely misjudge the distinction between reality and their imagination. Schizophrenias prevalence in the world was highlighted as 26th in the list of diseases, ranked according to their contribution to their overall burden to society as a whole according to a study done by Murray and Lopez, 1996. For example, it is estimated to have cost the NHS an outstanding  £4.7 billion in the UK during 2004/05 [25]. In addition in this essay I will discuss a range of elements, from what factors increase the susceptibility of inducing schizophrenia and the current treatments on offer that will help alleviate common symptoms. The disease itself has a broad influence on several other prominent factors, involving both the individuals themselves but also the global community, which will be later discussed, in regards to their social and economic co ntext. Schizophrenia is such an enormous problem since no permanent cure currently exists. Types of schizophrenia There are 3 specific classes of schizophrenia [2]: Paranoid schizophrenia Disorganized schizophrenia Catatonic schizophrenia Symptoms of paranoid schizophrenia The dominant feature of paranoid schizophrenia is excessive suspicion and delusions of being oppressed. Symptoms of disorganized schizophrenia Disorganized schizophrenia usually becomes visible at an earlier age in comparison to the other types of schizophrenia. Individuals with disorganized schizophrenia struggle with the responsibility of supporting themselves. Therefore may be incapable of fulfilling basics needs, for example, being able to feed themselves. The following includes additional symptoms of disorganized schizophrenia: Weakened ability to communicate Slurred speech Immature behaviour Expression of inappropriate feelings, in the wrong situation. Symptoms of catatonic schizophrenia The interference in movement summaries catatonic schizophrenia: This can either be a decline in motor neuron activity (stupor state) or a rise in motor neuron activity (excited state). Stuporous (a  state  of unresponsiveness) motor signs. Sudden stoppage of all intentional movement and dialogue. Excited motor signs.  Occasionally, schizophrenics may drastically change from a state of stupor to a state of extreme exhilaration. Throughout this hyperactive phase, they may illustrate rapid speech or uncontrollable movement and even act out in violence, either self-inflicting or to someone else Example of the Symptoms of Schizophrenia [6] The following summarises common symptoms that arise in schizophrenics: Hallucinations Sudden changes in behaviour Depression Delusions Loss of insight What causes schizophrenia? The cause for schizophrenia has been the subject of vigorous debate, with numerous elements being proposed, discounted or amended. In contrary to this, it has to this day not yet been diagnosed by scientists to be solely induced by one particular factor. It is however thought to be a result of a combination of elements, which differ in every patient. Recent studies have suggested that the following have been significant contributors consisting of a complex interaction between genetic and environmental factors, for example, prenatal development, genetics, psychology and neurobiology. [3] Genetic causes of schizophrenia Schizophrenia has a strong hereditary component which is shown to run in families, but no individual gene is accountable. It has been said that a combination of genes pose the potential to make people more susceptible to the disorder. In addition, people genetically predisposed to the condition have not always illustrated its symptoms, meaning that the biology of it will not guarantee having the condition. Studies imply that genes account for half (estimate) the risk of developing schizophrenia. Individuals with a parent or sibling who suffers from schizophrenia have a 10% chance of developing the illness, in comparison to the 1% chance of the general population. Identical twins who have precisely the same genetic make-up as one another, if one of the two siblings has schizophrenia, their twin has a 48% probability of developing it too. For example, Gottesman (1991) obtained data from the Maudsley twin register and then examined the records of 40 schizophrenics studies between 1948 and 1964.  Through statistical analysis he determined that 48% of the twins who were monozygotic (identical developed from one oocyte) happened to be concordant (when both have or both lack a given trait) and for dizygotic (not identical developed from two oocyte) only 16%.   This further demonstrates that schizophrenia is not solely genetic; otherwise the concordance for MZ twins would be 100%. Provided below is a table illustrating additional information regarding the risk of developing schizophrenia for different individuals [4]. Relatives with schizophrenia Chance of developing schizophrenia None 1 in 100 1 parent 1 in 10 1 identical twin (same genetic make-up) 1 in 2 1 non-identical twin (different genetic make-up) 1 in 80 Table 1: This table illustrates the risk of individuals developing schizophrenia if someone in their family has been diagnosed. Environmental causes of schizophrenia As discussed previously inherited genes make an individual greater exposed to schizophrenia and moreover environmental factors can too then act on this vulnerability to trigger the condition. In regards to the environmental aspects involved, on-going research is indicating the contribution of stress, either throughout pregnancy or at a further phase of life. High levels of stress activate schizophrenia by increasing the bodys manufacture of the steroid hormone cortisol. Cortisol normally controls the bodies fight or flight response, although long-term exposure can damage and reduce the number of nerve cells in the hippocampus, the brains primary memory centre. As a result theres a decline in the transmission of nerve impulses for memory recall, this damage results in memory loss and impaired learning, features associated with the mental disorder. Pregnancy where maternal stress is likely to be induced could possibly affect the development of the baby according to Gilmore Murrays study in 2006 [8] [23]. To determine whether prenatal stress alters neural, hormonal, and behavioural processes, in an experiment they carried out, pregnant rhesus monkeys were deliberately stressed frequently for 6 weeks of their pregnancy with various stimuli. Between 2-3 years of age, hippocampal volume, neurogenesis (generation of neurons), and cortisol levels were monitored in the offspring produced from both stressed and control pregnancies. Prenatal stress caused a reduced hippocampal volume and an inhibition of neurogenesis. These findings indicate that the prenatal environment can alter behaviour and affect the hippocampal structure of primates in a persistent manner. Furthermore if the mother happens to be anxious (stressed) while pregnant, there have been noticeable results suggesting reduced blood flow to the baby via the uterine arteries; blood vessels that supply nutrition and blood to the uterus. This could justify abnormalities in the development of the baby and the mothers high cortisol levels (a dominant stress hormone) could too pass onto the foetus. If adequate cortisol transports through the placenta from the mother to the foetus. This in turn could potentially affect the development of the brain and the future stress responses of the baby, thereby enhancing the risk of schizophrenia arising. Studies point to numerous stress-inducing environmental influences that may be related to schizophrenia, for example [22]: Inadequate oxygen levels during labour (due to prolonged labour or premature birth) Exposure to a virus during infancy e.g. T Gondi Drug abuse A relationship between marijuana use and the disorder has been suggested several years ago (Andreasson, Allebeck et al. 1987).   These conclusions have been validated by additional research.   Fundamentally, the deductions drawn from many of these reports were that marijuana use can induce psychosis.  Ã‚   For example, according to Thomas H, he stated the occurrence of psychotic symptoms amongst marijuana users in a random selection of volunteers from New Zealand. Fourteen percent of cannabis users described strange, unpleasant experiences such as hearing voices or becoming convinced that someone is trying to harm you or that you are being persecuted after consuming the substance. Such symptoms are frequent with schizophrenics too. [29] In addition Mathers DC conducted a study of patients residing in two London hospitals whose urine was investigated for the presence of cannabinoids (the active constituents of cannabis). They found a link between the presence of cannabinoids in urine and the disorder. This suggests a potential correlation and not entirely causual link, either that cannabis use increases the likely hood of being predisposed to a mental illness or that substance abuse is commonly adopted with post diagnosis [28]. The reliability of this data can be disputed even though it is a published study, a sample size made up of two individuals is notably small, especially when schizophrenia affects 1% of the global population, hence it may not be appropriate in statistical representation of the entire population because fewer risk factors can be taken into account to generate sound data, prove that a correlation exists and thus make any hypothesis meaningful. The cannabinoids found in cannabis, once consumed are thought to interfere with normal neural transmissions. The normal release of neurotransmitters, such as acetylcholine and dopamine (chemicals that help transmit impulses) from post synaptic neurons are seen to be inhibited (Gill et al, 1970). In turn excitatory postsynaptic currents in neurons were dramatically reduced. If this process becomes perpetual prominent effects of cannabinoids include disruption of psychomotor behaviour (such as speech and coordination) and shortà ¢Ã¢â€š ¬Ã‚ term memory impairment [33].  In addition psychomotor retardation consists of several symptoms that have been acknowledged in schizophrenia. However there is miniscule evidence that such impairments are permanent stated by Manuel Morrens study in 2006. Abnormal brain structure Due to the progression in neuroimaging, technology now allows scientists to examine functions in living organisms and in particular brain structure. Investigations involving schizophrenics have identified irregularities in brain structure according to Johnstone (1976) [27]. Such as the expansion of the ventricles (fluid-filled cavities), the decline in size and metabolic activity in particular brain regions. These brain ventricles signify an insufficiency in the volume of brain matter. In addition evidence of abnormally low activity in the frontal lobe; the area of the brain accountable for higher order functioning including; speech and decision-making has too been gathered. Which could explain why schizophrenics experience slurred speech. Regardless of the evidence of brain abnormalities, it is doubtful that schizophrenia is caused by a single issue in any one area of the brain. Moreover microscopic studies of dead brain tissue in schizophrenics have also illustrated slight alterati ons in the distribution of brain cells. However these defects are not characteristic of  all  people with schizophrenia, neither do they happen  solely in people with the disorder. [7][8] This image is of 28-year-old identical twins, one with schizophrenia and the other well. Hence it clearly illustrates two points: (1) schizophrenia is a brain disease with measurable structural and functional abnormalities in the brain; and (2) it is not solely a genetic disease, and that other biological elements contribute in its etiology. C:UsersRahmanDocumentsSchizopherniaschizophrenia-brains-identical-twins.jpg Figure 1 MRI scans of 28-year-old identical male twins showing the enlarged brain ventricles in the twin with schizophrenia (right) compared to his well brother (left) Neurotransmitters Brain cells need messages to be transported between them; neurotransmitters are the chemicals that carry out this requirement. Neurotransmitters and schizophrenia have shown to demonstrate a relationship since medicines that adjust the levels of neurotransmitters in the brain are recognized to alleviate a few of the symptoms of schizophrenia. Therefore schizophrenia could possibly be triggered by an alteration in the level of the two neurotransmitters serotonin and dopamine chemicals that help transmit nerve impulses from one nerve cell (neurone) to another across a synapse (gap between two neurones), investigations have suggested [7][8]. Lastly the antipsychotic drug chlorpromazine thought to reduce relapse time (suffer deterioration after a period of improvement), which too blocks dopamine-receptor complexes forming suggests that an imbalance of the two could possibly be the foundation of the problem. Genes In addition in 2006 a Gene linked to schizophrenia had been found, a University team from Edinburgh found people predisposed with what is called Neuregulin (gene) had a higher chance of developing similar psychotic symptoms. The longitudinal study followed a group of 200, of the same age and gender, for a period of 10 years. [9][10][11] This study could be deemed reliable to an extent, seeing as though 10 years is an extremely substantial amount of time, hence a vast amount of data could be collected to either support or disprove the theory. In addition by following individuals of the same age and gender, further risk factors that could influence the results were controlled. Meaning the data would be valid, because any results would be more likely to be influenced by genes alone. Neuregulin 3 is clearly one more gene to add to the few currently known to contribute to schizophrenia, says David Valle, director of the McKusick-Nathans Institute of Genetic Medicine at Hopkins. Pregnancy and birth complications The following circumstances increase the risk of the child developing schizophrenia later in life [8]: Exposure to a virus while in the womb Asphyxia (Lack of oxygen) during birth Malnutrition during pregnancy (Susser et al. 1996) How is schizophrenia treated? Due to the cause for schizophrenia still being undetermined, treatments target alleviating the symptoms. These include the use of both antipsychotic medication and various other psychosocial management techniques. Antipsychotic drugs assist in normalizing the biochemical imbalances that cause schizophrenia. Antipsychotic medications Medications used to treat schizophrenia are referred to as antipsychotics. Antipsychotics are dopamine antagonists they block receptors on the surface of neurons. How do antipsychotic drugs work? Neurons (nerve cells) carry electrical impulses through their branches. Neurons communicate chemically by sending out bursts of chemical signals (neurotransmitters NTs) into the synapse (space between neurons) and then sticking to receptors on receiving neuron. Receptors are shaped to fit with specific NTs and generate a new signal/change in the receiving cell. Molecules of antipsychotic drugs are deliberately shaped so that they stick to the dopamine receptors first; therefore preventing the binding of NTs so no signal goes through to the post-synaptic/receiving cell. [30] G:BlackBerrypicturesIMG00079-20130303-1521.jpg Figure 2 The picture above illustrates how the antipsychotic drug works by blocking the receptors on the post-synaptic neuron. The following include frequently used medicine [13]: Chlorpromazine C:UsersRahmanDocumentsSchizopherniaChlorpromazine 2D skeletal.png Figure 3 This picture illustrates the chemical composition of the antipsychotic Clozapine.Haloperidol Ondansetron Clozapine Clozapine as mentioned above is an effective drug utilized in treating psychotic symptoms, for example, hallucinations or long breaks with reality. Because antipsychotic drugs inhibit neurotransmitter and receptor complexes forming, such nerve impulses cannot be passed on through the neural pathway. In turn this prevents such thoughts from being processed by the CNS (central nervous system), including the brain and hence the patient doesnt encounter similar problems as before. However it too has its drawbacks, it can occasionally result in the loss of white blood cells which assist the immune system to fight off infection. As a result clozapine users require regular weekly blood tests in order to have their white blood cell count checked [26]. Moreover such a side effect can become an issue where health services are limited in availability, as well as the problem of being able to cope with the cost of blood tests and medicine, making treatment with clozapine demanding for a large majority of individuals. However clozapine is potentially valuable for those who have developed a resistance to alternative antipsychotic medication. What are the side effects? Further side effects may occur when schizophrenics begin taking their medication. Side effects of many antipsychotics include [14]: Tiredness Light-headedness Obscured vision Increased heart rate Inflammation Menstrual complications for women. One of the challenges with any form of medication is that a minority of individuals unable to tolerate the adverse side effects of the drug prescribed for their condition terminate its use into several months of their treatment. Furthermore in reference to a more serious medical note, persistent use (over several years) of antipsychotic drugs pose the risk of developing tardive dyskinesia (TD), a disorder categorised by involuntary movements. This may involve jerk movements of the limps (arms or legs) and certain other features of the body. However it only occurs in between 15-20% of all cases. The symptoms of TD are minor, to the extent where patients could possibly be unaware [13]. Its cause is supposed to be a result of prolonged inhibition of dopamine D2  receptors (a cell that dopamine binds to) which is thought to cause a surge in the quantity of D2  receptors in the striated section of the brain (regulates muscle contraction). This increase of D2  receptors enhances the chance of dopamine-receptor complexes forming, thereby leading to further impulsive muscle contraction. [34] Moreover typical antipsychotics can lead to severe obesity and alterations in a persons metabolism. This in turn can increase the possibility of diabetes and high cholesterol levels forming (therefore there is a need for doctors to regularly monitor a persons weight, glucose levels and liquid levels). Psychosocial Treatments (Alternative Treatment) Along with the more common psychotic symptoms of schizophrenia, for example, hallucinations, which antipsychotic drugs have demonstrated to alleviate. Patients are still left dealing with the behavioural difficulties of the condition. This treatment aims to ease psychological distress through a more personal and interactive process, rather than the use of medication. The following include methods in helping to treat these behavioural issues [5]: Individual/Group Psychotherapy consists of repeated scheduled talks between the patient(s) and a psychiatrist. Giving him/her the opportunity to discuss the difficulties that leave them feeling distressed in an intimate and safe environment. In turn the weight off having to deal with the problem alone can be removed, the psychiatrist can then provide an explanation for the suffering that is progressive that is, the patient understands something can be done to mend the situation. This leads them to conducting themselves in a healthier and active manner, whether it is thinking more positively or they learn how to maintain better relationships. This seems to be effective because the patient is given the self-belief that any improvements are down to their own merit. Family Education This involves teaching several coping techniques to families for the purpose of dealing more effectively with their ill relative. Relatives can be crucial tools when dealing with schizophrenics, with their support and guidance patients can find some form of normality and alleviate the effects of solitude, just one of the many symptoms of the condition. In general with the combination of medicinal and psychosocial treatment, patients quality of life of can be drastically improved. However dont be deceived, the treatment process for some individuals can be difficult to follow, in reference to drug side effects treatment may be discontinued. This is where relatives can be vital in assisting that patients do not relapse. C:UsersRahmanDocumentsSchizopherniapsychiatry-couch2.jpg Figure 4 this picture illustrates a comfortable environment, typically in a psychiatrics place of practice where the patient can discuss his feelings on topics that cause concern and thereby hopefully reduce his psychological suffering. This should improve his quality of life. Electroconvulsive therapy (ECT) ECT is scarcely implemented in the treatment of schizophrenia (e.g. exceptions may include when there is a high risk of suicide). The following describes how the treatment would typically be conducted [32]; The patient will have a pulse oximeter connected to them, in order to monitor blood oxygen levels. Electrodes will then be placed onto the recipients chest so that the electrical activity across the patients heart can be observed using an electrocardiogram (ECG) In addition an  electroencephalogram (EEG)  will too be simultaneously utilized to monitor brain activity The monitoring of blood pressure is imperative, so that any faults during the treatment can be identified immediately; hence a blood pressure cuff is positioned onto the recipients arm. Using a sharp hollow needle connected to a transparent tube, access to the blood vessel is obtained for the administration of drugs A sedated state is induced using the appropriate drugs to prevent erratic movement and a constant supply of oxygen is provided throughout the procedure. Next a bite block is placed in the patients mouth because the jaw tightens during the treatment and weakened teeth could break. Additional electrodes are placed onto the head; the electrical current is then applied through the scalp of the brain causing a seizure to occur. What the seizures are thought to do vary, suggestions include causing alterations in brain chemistry, especially in the balance of neurotransmitters, and hence the brain can function normally because nerve impulses are neither slowed down or too fast. An alternative theory suggests that ECT can stimulate the growth of new cells and nerve pathways in certain areas of the brain, as a resultà ¢Ã¢â€š ¬Ã‚ ¦ which can quickly inverse the symptoms of such an illness, the specifics yet remain unknown (Wahlund B   Von Rosen D, 2003). Evidence from randomised control trials (RCTs) have shown restricted success, lasting short term (Cochrane Schizophrenia Group, 1999). The typical side effects that arise seem to include; muscle aches, headaches and memory loss instantly after the procedure. Disadvantages of Psychosocial Treatments With any form of treatment, certain limitations will always follow; this includes that psychotherapy will naturally take a significantly longer span of time, in order for noticeable improvements to be seen in patients in comparison to drug therapy [24]. This is because psychotherapy very much depends on the use of the patients own mental experiences to bring about the desired changes, whereas drugs will have the desired effect regardless. Moreover in regards to the financial aspect of the treatment, it can too place a severe burden on health services to facilitate either group or individual therapy sessions at the tax payers expense, it has been estimated to cost society  £2 Billion in direct cost of treatment in 2004/05 (Mangalore R, Knapp M, 2007). In addition psychotherapy alone is not completely successful and effective in people with  a severe psychological state, so drugs can sometimes be the only form of treatment. Research into Stem Cell Treatment for Schizophrenia (Potential Treatment in the Future) Stem cells are unspecialized cells that hold the potential to differentiate into any type of cell found within the human body [19]. The National Institutes of Health states that stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. [15] Stem cells hold the potential of great breakthroughs in the science community, in this case the possibility of an effective cure being manufactured in the future. However since our current limitations with the research, for example, problems with deliberate cell differentiation and the undetermined cause for schizophrenia such research has been delayed not till another 50-100 years so our understanding of stem cells is at an adequate level. However there are ethical issues that would arise in treating schizophrenia with stem cell therapy once scientifically possible. For the predominant reason that the pluripotent stem cells needed for research are solely present in embryos and the extraction of these would result in its death. For those people who believe that life begins at conception, this may be perceived as murder, seeing as though a viable life had been forcefully refused and to destroy it is immoral [15]. Furthermore like any other new technology, because we have not had a vast amount of time to study it to gather sufficient information on its broad impact; it is completely unknown what the long-term effects of such an intrusion with nature could mean to society. Such as will patients grow an extra arm in 10 years from the point of its use? Lastly stem cells derived from embryos that are not a patients own may be identified as a foreign body, so may be rejected. Therefore stem cell therapy may not always be appro priate. Although in order to balance the argument, stem cell therapy could be substantially beneficial to our society, it could potentially mean a cure, where patients would no longer suffer from the condition after treatment, resulting in a better quality of life. It could therefore replace conventional types of treatment e.g. medicine that are prescribed on a regular/life time basis. Thereby removing the pain inflicted on peoples lives caused by side effects and limits they can place such as, not being able to work from being too tired but more importantly reducing the burden placed on society by schizophrenia, for example, the financial expense of producing drugs. Furthermore if the development of new drugs in this area are no longer as important, a by-product could mean fewer pressures to experiment on animals, which is a constituent of the drug development cycle. Hence animals would be subject to less brutality such experiments hold. With anything, the pros and cons must be weighted out , so that a decision suiting the majority is made. C:UsersRahmanDocumentsSchizopherniaStem cells.jpg Figure 5 This illustration depicts pluripotent stem cells ability to differentiate into a range of cells found in our bodies, for example, neurons. Modelling schizophrenia using human induced pluripotent stem cells Research carried out by Professor Fred Gage, an expert in genetics has successfully been able to induce pluripotent stem cells (iPSCs) created from schizophrenic patients. Sages study published in the journal Nature (April 13, 2011) suggests both that neurons formed from such individuals made fewer links with each other in comparison to neurons found in non-sufferers of the condition. Such research will have a variety of beneficial impacts, including as stated by Gage [20][21]: With further research there is potential of possibly replacing such abnormal neurons related to the condition with healthy ones.This model not only affords us the opportunity to look at live neurons from schizophrenia patients and healthy individuals to understand more about the disease mechanism, but also to screen for drugs that may be effective in reversing it. C:UsersRahmanDocumentsSchizopherniastem cells from schizophrenics.jpg Figure 6 This picture illustrates the healthy neural pathway in the brain generated from schizophrenia patient-derived induced pluripotent stem cells. The Cost of Schizophrenia to Society: Economical Implication Also, for the government, especially in the UK where health care is provided free of charge, people with schizophrenia can be a severe financial constraint. Because such patients suffer from numerous debilitating  symptoms, including depression and hallucinations. Doctors will prescribe medication in order to combat this, in this instance antidepressants (e.g. prozac) or antipsychotics of which both need to be paid for. This cost is financed by the tax payers, the problem doesnt stop there. With any drug, side effects are present as a result of its usage; doctors too prescribe further medicine to treat these symptoms. The domino effect of over scribing medicine leaves the country with an overwhelming financial cost. In regards to Mangalore and Knapps study in 2007 indirect societal costs for schizophrenia were estimated to once have had an expenditure of  £4.7 billion in the UK in 2004/05 [25]. According to Marwaha Johnsons journal published in 2004, it showed that amongst those with long-term mental health problems in particular schizophrenia, only 24% were employed [18]. As a result, in order for such people to maintain a standard of living, such as being able to purchase food and pay rent on their homes, they will usually claim an incapacity benefit entitling them to some money per week. This cost will be supplemented by the government once again, adding to the total financial burden left by mental disorder patients. Social Implication The improper treatment and dismissal of the symptoms of schizophrenia can be overwhelming for the patient and those surrounding him/her.  Examples of the possible effects of schizophrenia include the following: Suffering from schizophrenia can make being employed and retaining relationships immensely challenging, because such patients frequently suffer from relapses, typically involving hallucinations; whereby the patient claims to see things that arent really there. This can cause them to develop trust issues and communication problems, sometimes feeling that they are being persecuted by the individuals themselves. As a result, the patients keep themselves isolated, disregarding their support or even presence. This may ultimately lead to the loss of relationships, which can have a psychological toll on the family members too who care for the person, knowing that they may never truly embrace the same person again. In addition schizophrenics ar

Body Modification in America Essays -- essays research papers

Body modification in American Culture In recent years tattooing and body piercing have become increasingly prevalent in popular culture. These forms of body modification are no longer tools used by criminals and gang member, showing their role in society. These practices are used by many of teenagers and young adults in our society today. In fact many of these practices have been a positive trend in American culture, giving adolescents a way of expressing themselves Studies have revealed a positive correlation between risky behaviors (such as the use of drugs, cigarettes, and alcohol) and participation in body modification. There is a shortage of available research, however, investigating the relationship between body modification and behaviors of high-risk such as driving while intoxicated and unsafe sexual practices. The current study attempted to bridge this gap in the literature by examining body modification participation and involvement in very high-risk behaviors common to a college student population. Two hypotheses were examined. First, it was hypothesized that a positive relationship between participation in body modification and very high-risk activities would be found. Secondly, it was hypothesized that self-esteem would mediate the relationship between body modification and very high-risk behaviors. The Cognitive Appraisal of Risky Events--Revised (Fromme, D'Amico, & Katz, 1999; Katz, Fromme, & D'Amico, 2000) and The Coopersmith Inv entory (Coopersmith, 1...